The increasing development of biotechnology has laid the ground to achieve modern technologies and improved their efficacy.

In this regard, scientific societies and well-known companies involving in biotechnology are seeking to reach new methods for improvement of their product quality.

One of the most noticeable aspects of the advances is to make an effort in improving the efficacy of antibodies that particularly, in recent years, used in treatment of cancers, autoimmune and infectious diseases. Therefore, researchers have focused their studies to achieve this goal through modifications in genetic structures of antibodies and recombinant proteins.

Production of single chain antibodies (SCA) and their humanization which are used in therapeutic and diagnostic purposes are other activities since targeting specific tumor antigens could be a difficult application, by means of genetic engineering techniques   injected specific tumor antigen/ peptide causes immune system to produce antibody against this antigen which resulted in cell death (apoptosis).

These antibodies which are firstly produced in mouse can not be appropriately used in human immune system, but humanization of monoclonal antibodies by genetic engineering makes them more applicable in therapeutic purposes.

Filed of Activity:

1. production of recombinant proteins with the aim of producing vaccine for prevention, treatment and screening of diseases particularly cancer, autoimmune and infectious diseases
2. production of single chain antibodies (SCA) via genetic engineering for diagnostic and therapeutic purposes
3. Humanization of antibodies through genetic engineering for treatment of diseases particularly cancer
4. Molecular manipulation of antibodies and recombinant proteins to apply them in medicine and industry
5. Production and application of new anti-cancer vaccines by analysis of expression profile and selection of cancer cell markers
6. Application of genetic engineering techniques for creation of biological products used in cancer immunotherapy and other diseases

Faculty members:

• Dr Hodjattallah Rabbani
• Dr Mahmood Jeddi Tehrani
• Dr Mohammad Babashamsi
• Dr Saeed Talebi
• Dr Saeed Zareie
• Reza Hadavi
• Farhad Khosravi
• Shaghayegh Emami
• Negah Ahmadvand
• Azam Hemmati
• Raheleh Farahani
• Dr Masoud Taghizadeh
• Zahra Nouchi